Premium
Identification of nuclear localization signals within the human BCOR protein
Author(s) -
Surapornsawasd Thunyaporn,
Ogawa Takuya,
Moriyama Keiji
Publication year - 2015
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/j.febslet.2015.05.046
Subject(s) - corepressor , nuclear localization sequence , phenotype , genetics , biology , mutation , transcriptional activity , gene , repressor , transcription factor
Mutations in the BCL‐6 corepressor ( BCOR ) gene, which encodes a transcriptional corepressor, were described to cause oculofaciocardiodental syndrome (MIM300166). The purpose of this study was to localize the classical nuclear localization signals (NLSs) of the BCOR using reported human BCOR mutations with comparable phenotypes. The genotype–phenotype correlation among the mutations could not be clearly explained; however, the classical NLSs were identified at two possible sites; RVDRKRKVSGD at aa1131–1141 (NLS1) and LKAKRRRVSK at aa1158–1167 (NLS2). In addition, according to our results, NLS2 displayed a more efficient nuclear import function than NLS1.