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TSPAN1 functions as an oncogene in gastric cancer and is downregulated by miR‐573
Author(s) -
Lu Zhengmao,
Luo Tianhang,
Nie Mingming,
Pang Tao,
Zhang Xin,
Shen Xiaojun,
Ma Liye,
Bi Jianwei,
Wei Guo,
Fang Guoen,
Xue Xuchao
Publication year - 2015
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/j.febslet.2015.05.044
Subject(s) - oncogene , downregulation and upregulation , tetraspanin , carcinogenesis , cell cycle , cancer , cancer research , biology , cell growth , microrna , cell , rna interference , gene , genetics , rna
Tetraspanin 1 (TSPAN1) has been reported to be upregulated in gastric cancer (GC). However, whilst TSPAN1 is positively correlated with clinical stage and negatively correlated with survival rates, its function in GC remains elusive. Here we show that expression of TSPAN1 is significantly higher in GC tissues compared to non‐cancerous tissues. Furthermore, we demonstrate that RNAi‐mediated down‐regulation of TSPAN1 expression markedly blocks GC cell proliferation, cell cycle progression and invasive activity. We identified TSPAN1 as a novel target gene of miR‐573. Overexpression of miR‐573 suppressed proliferation and invasion of GC cells by down‐regulation of TSPAN1 expression. Restoration of TSPAN1 rescued the effects of miR‐573 overexpression. Therefore, our findings suggest that the miR‐573/TSPAN1 axis is important in the control of gastric carcinogenesis.