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SIRT1 is a regulator of autophagy: Implications in gastric cancer progression and treatment
Author(s) -
Qiu Guanglin,
Li Xuqi,
Che Xiangming,
Wei Chao,
He Shicai,
Lu Jing,
Jia Zongliang,
Pang Ke,
Fan Lin
Publication year - 2015
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/j.febslet.2015.05.042
Subject(s) - autophagy , carcinogenesis , cancer , biology , cancer research , context (archaeology) , regulator , programmed cell death , cancer cell , mechanism (biology) , cell growth , microbiology and biotechnology , apoptosis , gene , genetics , paleontology , philosophy , epistemology
Silent mating type information regulation 1 (SIRT1) is implicated in tumorigenesis through its effect on autophagy. In gastric cancer (GC), SIRT1 is a marker for prognosis and is involved in cell invasion, proliferation, epithelial‐mesenchymal transition (EMT) and drug resistance. Autophagy can function as a cell‐survival mechanism or lead to cell death during the genesis and treatment of GC. This functionality is determined by factors including the stage of the tumor, cellular context and stress levels. Interestingly, SIRT1 can regulate autophagy through the deacetylation of autophagy‐related genes (ATGs) and mediators of autophagy. Taken together, these findings support the need for continued research efforts to understand the mechanisms mediating the development of gastric cancer and unveil new strategies to eradicate this disease.