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Secretin receptor involvement in prion‐infected cells and animals
Author(s) -
Kimura Tomohiro,
Nishizawa Keiko,
Oguma Ayumi,
Nishimura Yuki,
Sakasegawa Yuji,
Teruya Kenta,
Nishijima Ichiko,
Doh-ura Katsumi
Publication year - 2015
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/j.febslet.2015.05.039
Subject(s) - secretin , receptor , biology , incubation , endocrinology , microbiology and biotechnology , medicine , genetics , biochemistry , pancreas
The cellular mechanisms behind prion biosynthesis and metabolism remain unclear. Here we show that secretin signaling via the secretin receptor regulates abnormal prion protein formation in prion‐infected cells. Animal studies demonstrate that secretin receptor deficiency slightly, but significantly, prolongs incubation time in female but not male mice. This gender‐specificity is consistent with our finding that prion‐infected cells are derived from females. Therefore, our results provide initial insights into the reasons why age of disease onset in certain prion diseases is reported to occur slightly earlier in females than males.