Premium
Architectural proteins, transcription, and the three‐dimensional organization of the genome
Author(s) -
Cubeñas-Potts Caelin,
Corces Victor G.
Publication year - 2015
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/j.febslet.2015.05.025
Subject(s) - chromatin , genome , biology , computational biology , enhancer , chia pet , genomic organization , transcription (linguistics) , genetics , transcription factor , evolutionary biology , chromatin remodeling , dna , gene , linguistics , philosophy
Architectural proteins mediate interactions between distant sequences in the genome. Two well‐characterized functions of architectural protein interactions include the tethering of enhancers to promoters and bringing together Polycomb‐containing sites to facilitate silencing. The nature of which sequences interact genome‐wide appears to be determined by the orientation of the architectural protein binding sites as well as the number and identity of architectural proteins present. Ultimately, long range chromatin interactions result in the formation of loops within the chromatin fiber. In this review, we discuss data suggesting that architectural proteins mediate long range chromatin interactions that both facilitate and hinder neighboring interactions, compartmentalizing the genome into regions of highly interacting chromatin domains.