Premium
PI3K‐C2α: One enzyme for two products coupling vesicle trafficking and signal transduction
Author(s) -
Campa Carlo C.,
Franco Irene,
Hirsch Emilio
Publication year - 2015
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/j.febslet.2015.05.001
Subject(s) - endocytosis , microbiology and biotechnology , signal transduction , phosphorylation , receptor , pi3k/akt/mtor pathway , receptor mediated endocytosis , vesicle , biology , cell surface receptor , chemistry , biochemistry , membrane
The spatial restriction of phosphorylated phosphoinositides generated downstream activated membrane receptors is critical for proper cell response to environmental cues. The α isoform of class II PI3Ks, PI3K‐C2α, has emerged as a modulator of receptor localization, acting both in the control of receptor endocytosis and resensitization. This unexpectedly versatile enzyme was found to differentially produce two distinct 3‐phosphorylated phosphoinositides and to selectively control distinct steps of vesicular traffic such as endocytosis and recycling. This review focuses on the latest discoveries regarding PI3K‐C2α function in vesicle trafficking and its impact on cell biology and mammalian embryonic development.