Premium
Long non‐coding RNA HOTAIR modulates c‐KIT expression through sponging miR‐193a in acute myeloid leukemia
Author(s) -
Xing Chong-yun,
Hu Xiao-qu,
Xie Fei-yan,
Yu Zhi-jie,
Li Hai-ying,
Wu Jian-bo,
Tang Li-yuan,
Gao Shen-meng
Publication year - 2015
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/j.febslet.2015.04.061
Subject(s) - hotair , myeloid leukemia , cancer research , gene knockdown , long non coding rna , myeloid , biology , competing endogenous rna , leukemia , apoptosis , rna , immunology , gene , genetics
HOTAIR is significantly overexpressed in various cancers and facilitates tumor invasion and metastasis. However, whether HOTAIR plays oncogenic roles in acute myeloid leukemia (AML) is still unknown. Here, we report that HOTAIR expression was obviously increased in leukemic cell lines and primary AML blasts. Clinically, AML patients with higher HOTAIR predicted worse clinical outcome compared with those with lower HOTAIR. Importantly, HOTAIR knockdown by small hairpin RNA inhibited cell growth, induced apoptosis, and decreased number of colony formation. Finally, HOTAIR modulated c‐KIT expression by competitively binding miR‐193a. Collectively, our data suggest that HOTAIR plays an important oncogenic role in AML and might serve as a marker for AML prognosis and a potential target for therapeutic intervention.