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Growth control mechanisms in neuronal regeneration
Author(s) -
Doron-Mandel Ella,
Fainzilber Mike,
Terenzio Marco
Publication year - 2015
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/j.febslet.2015.04.046
Subject(s) - regeneration (biology) , chemistry , microbiology and biotechnology , neuroscience , biophysics , biology
Neurons grow during development and extend long axons to make contact with their targets with the help of an intrinsic program of axonal growth as well as a range of extrinsic cues and a permissive milieu . Injury events in adulthood induce some neuron types to revert to a regenerative state in the peripheral nervous system (PNS). Neurons from the central nervous system (CNS), however, reveal a much lower capacity for regenerative growth. A number of intrinsic regeneration‐promoting mechanisms have been described, including priming by calcium waves, epigenetic modifications, local mRNA translation, and dynein‐driven retrograde transport of transcription factors (TFs) or signaling complexes that lead to TF activation and nuclear translocation. Differences in the availability or recruitment of these mechanisms may partially explain the limited response of CNS neurons to injury.