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RSRC1 SUMOylation enhances SUMOylation and inhibits transcriptional activity of estrogen receptor β
Author(s) -
Chen Lihan,
Li Weini,
Qiu Weiyi,
Ren Wen,
Li Qincao,
Han Baiyu,
Zhou Lei,
Cheng Long,
Zhang Hao,
Ye Qig
Publication year - 2015
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/j.febslet.2015.04.035
Subject(s) - sumo protein , estrogen receptor , microbiology and biotechnology , transcription factor , rnf4 , transcription (linguistics) , chemistry , biology , zinc finger , ubiquitin , biochemistry , gene , genetics , linguistics , philosophy , cancer , breast cancer
The transcription factor estrogen receptor β (ERβ) plays roles in the central nervous, endocrine, cardiovascular, and immune systems. ERβ can be SUMOylated. However, the underlying mechanism remains unclear. Here, we show that RSRC1/SRrp53 interacts with ERβ and SUMOylation of RSRC1 is required for regulation of PIAS1‐mediated ERβ SUMOylation. RSRC1 promotes ERβ SUMOylation through enhanced interaction between ERβ and PIAS1. RSRC1 represses ERβ transcriptional activity through regulation of ERβ SUMOylation. By establishing RSRC1 as a novel cofactor for SUMOylation, our data provide insight into regulation of ERβ SUMOylation and indicate that SUMOylation of one protein can regulate another protein SUMOylation.