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The seventh zinc finger motif of A20 is required for the suppression of TNF‐α‐induced apoptosis
Author(s) -
Yamaguchi Noritaka,
Yamaguchi Naoto
Publication year - 2015
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/j.febslet.2015.04.022
Subject(s) - zinc finger , ubiquitin , ubiquitin ligase , apoptosis , tumor necrosis factor alpha , deubiquitinating enzyme , chemistry , microbiology and biotechnology , ring finger , biology , cancer research , biochemistry , transcription factor , immunology , gene
The ubiquitin‐editing enzyme A20 suppresses nuclear factor‐κB (NF‐κB) activation and tumor necrosis factor‐α (TNF‐α)‐induced apoptosis in a deubiquitinating and ubiquitin ligase activity‐dependent manner. Although recent studies revealed that A20 regulates NF‐κB independently of its enzymatic activity through its seventh zinc finger motif (ZnF7), the involvement of ZnF7 in TNF‐α‐induced apoptosis is not clear. In this study, ZnF7 was found to be important for A20‐mediated suppression of TNF‐α‐induced apoptosis. We also found that the ubiquitin ligases cIAP1/2 are required for A20 to suppress TNF‐α‐induced apoptosis. Because A20 binds to cIAP1/2 through ZnF7, these results suggest that A20 may control cIAP1/2 when suppressing TNF‐α‐induced apoptosis.