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Baicalin promotes embryo adhesion and implantation by upregulating fucosyltransferase IV (FUT4) via Wnt/beta‐catenin signaling pathway
Author(s) -
Zhang Yu-Mei,
Zhang Yuan-Yuan,
Bulbul Ahmmed,
Shan Xiu,
Wang Xiao-Qi,
Yan Qiu
Publication year - 2015
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/j.febslet.2015.04.011
Subject(s) - baicalin , endometrium , embryo , wnt signaling pathway , fucosyltransferase , catenin , fucosylation , andrology , microbiology and biotechnology , endocrinology , signal transduction , medicine , biology , chemistry , fucose , glycoprotein , biochemistry , gene , high performance liquid chromatography , chromatography
Glycosylation plays a significant role in determining the receptivity of the uterine endometrium to embryo. Fucosyltransferase IV (FUT4) is expressed stage‐specifically in the uterine endometrium of mammalians, and considered as a marker of the endometrial receptivity. Baicalin, a monomer of flavonoids, is known to have functions in improving reproduction. However, the mechanism by which baicalin regulates the expression of FUT4 in embryo‐endometrium adhesion remains unclear. Our results showed that baicalin significantly increased FUT4 mRNA and protein expression levels both in human endometrial cells and mouse endometrial tissue, and consistently elevated embryo adhesion rate during implantation in vitro and embryonic implantation competence in pregnant mouse. This study suggests that baicalin facilitates endometrial reproduction via elevating FUT4 expression through Wnt/β‐catenin signaling pathway.