Premium
EGFR/ERBB receptors differentially modulate sebaceous lipogenesis
Author(s) -
Dahlhoff Maik,
Camera Emanuela,
Ludovici Matteo,
Picardo Mauro,
Müller Udo,
Leonhardt Heinrich,
Zouboulis Christos C.,
Schneider Marlon R.
Publication year - 2015
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/j.febslet.2015.04.003
Subject(s) - downregulation and upregulation , erbb3 , lipogenesis , erbb , sebaceous gland , epidermal growth factor receptor , receptor , chemistry , endocrinology , medicine , cancer research , biology , lipid metabolism , biochemistry , gene
The roles of the epidermal growth factor receptor (EGFR) in sebaceous glands remain poorly explored. We show that human sebocytes express EGFR and lower levels of ERBB2 and ERBB3, all receptors being downregulated after the induction of lipid synthesis. Nile red staining showed that siRNA‐mediated downregulation of EGFR or ERBB3 increases lipid accumulation, whereas ERBB2 downregulation has no effect. Spectrometry confirmed induction of triglycerides after EGFR or ERBB3 downregulation and revealed induction of cholesteryl esters after downregulation of EGFR, ERBB2 or ERBB3. Thus, EGFR/ERBB receptors differentially modulate sebaceous lipogenesis, a key feature of sebaceous gland physiology and of several skin diseases.