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Mesenchymal‐stem‐cell‐derived exosomes accelerate skeletal muscle regeneration
Author(s) -
Nakamura Yoshihiro,
Miyaki Shigeru,
Ishitobi Hiroyuki,
Matsuyama Sho,
Nakasa Tomoyuki,
Kamei Naosuke,
Akimoto Takayuki,
Higashi Yukihito,
Ochi Mitsuo
Publication year - 2015
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/j.febslet.2015.03.031
Subject(s) - myogenesis , mesenchymal stem cell , regeneration (biology) , microvesicles , angiogenesis , microbiology and biotechnology , skeletal muscle , paracrine signalling , biology , stem cell , exosome , myocyte , transplantation , immunology , cancer research , microrna , anatomy , medicine , genetics , receptor , gene
Mesenchymal stem cell (MSC) transplantation is used for treatment of many diseases. The paracrine role of MSCs in tissue regeneration is attracting particular attention. We investigate the role of MSC exosomes in skeletal muscle regeneration. MSC exosomes promote myogenesis and angiogenesis in vitro, and muscle regeneration in an in vivo model of muscle injury. Although MSC exosomes had low concentrations of muscle‐repair‐related cytokines, a number of repair‐related miRNAs were identified. This study suggests that the MSC‐derived exosomes promote muscle regeneration by enhancing myogenesis and angiogenesis, which is at least in part mediated by miRNAs such as miR‐494.