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Mitsugumin 56 (hedgehog acyltransferase‐like) is a sarcoplasmic reticulum‐resident protein essential for postnatal muscle maturation
Author(s) -
Van Bo,
Nishi Miyuki,
Komazaki Shinji,
Ichimura Atsuhiko,
Kakizawa Sho,
Nakanaga Keita,
Aoki Junken,
Park Ki-Ho,
Ma Jianjie,
Ueyama Tomomi,
Ogata Takehiro,
Maruyama Naoki,
Takeshima Hiroshi
Publication year - 2015
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/j.febslet.2015.03.028
Subject(s) - endoplasmic reticulum , skeletal muscle , endocrinology , biology , microbiology and biotechnology , medicine , acyltransferase , knockout mouse , sarcoplasm , chemistry , biochemistry , enzyme , receptor
Mitsugumin 56 (MG56), also known as the membrane‐bound O‐acyl‐transferase family member hedgehog acyltransferase‐like, was identified as a new sarcoplasmic reticulum component in striated muscle. Mg56 ‐knockout mice grew normally for a week after birth, but shortly thereafter exhibited a suckling defect and died under starvation conditions. In the knockout skeletal muscle, regular contractile features were largely preserved, but sarcoplasmic reticulum elements swelled and further developed enormous vacuoles. In parallel, the unfolded protein response was severely activated in the knockout muscle, and presumably disrupted muscle development leading to the suckling failure. Therefore, MG56 seems essential for postnatal skeletal muscle maturation.