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Negative regulation of hepatitis B virus replication by forkhead box protein A in human hepatoma cells
Author(s) -
Okumura Nobuaki,
Ikeda Masanori,
Satoh Shinya,
Dansako Hiromichi,
Sugiyama Masaya,
Mizokami Masashi,
Kato Nobuyuki
Publication year - 2015
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/j.febslet.2015.03.022
Subject(s) - foxa2 , foxa1 , hepatitis b virus , downregulation and upregulation , biology , virology , hepatitis b virus pre beta , viral replication , transcription (linguistics) , transcription factor , virus , genetics , gene , hepatitis b virus dna polymerase , linguistics , philosophy
Hepatitis B virus (HBV) replication is controlled by liver‐enriched transcriptional factors, including forkhead box protein A (FOXA) members. Here, we found that FOXA members are directly and indirectly involved in HBV replication in human hepatic cells. HBV replication was elevated in HuH‐7 treated with individual FOXA members‐specific siRNA. Reciprocally, the downregulation of HBV replication was observed in FOXA‐induced HuH‐7. However, the mechanism of downregulation is different among FOXA members at the level of HBV RNA transcription, such as precore/pg RNA and 2.1 kb RNA. In addition, FOXA1 and FOXA2 suppressed nuclear hormone receptors, such as HNF4α, that are related to HBV replication.