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MicroRNA‐184 modulates canonical Wnt signaling through the regulation of frizzled‐7 expression in the retina with ischemia‐induced neovascularization
Author(s) -
Takahashi Yusuke,
Chen Qian,
Rajala Raju V.S.,
Ma Jian-xing
Publication year - 2015
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/j.febslet.2015.03.010
Subject(s) - wnt signaling pathway , frizzled , retina , microbiology and biotechnology , neovascularization , lrp5 , lrp6 , microrna , signal transduction , ischemia , biology , chemistry , cancer research , angiogenesis , medicine , neuroscience , biochemistry , gene
Aberrant activation of Wnt signaling contributes to ischemia‐induced retinal neovascularization in oxygen‐induced retinopathy (OIR), although the underlying mechanism is so far unclear. Here, we show that microRNA‐184 (miR‐184) is significantly down‐regulated in the retina of OIR mice, and miR‐184 negatively modulates Wnt signaling both in vivo and in vitro . Furthermore, we show that the Wnt receptor, frizzled‐7, is a downstream target of miR‐184, and delivery of miR‐184 mimic inhibits Wnt signaling in the OIR retina. These results suggest that decreased levels of miR‐184 are responsible, at least in part, for the aberrant activation of Wnt signaling in ischemia‐induced retinal neovascularization.