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A Drosophila ‐centric view of protein tyrosine phosphatases
Author(s) -
Hatzihristidis Teri,
Desai Nikita,
Hutchins Andrew P.,
Meng Tzu-Ching,
Tremblay Michel L.,
Miranda-Saavedra Diego
Publication year - 2015
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/j.febslet.2015.03.005
Subject(s) - drosophila (subgenus) , protein tyrosine phosphatase , phenotype , biology , drosophila melanogaster , gene , complement (music) , computational biology , phosphatase , human disease , tyrosine , genetics , microbiology and biotechnology , phosphorylation , biochemistry , complementation
Most of our knowledge on protein tyrosine phosphatases (PTPs) is derived from human pathologies and mouse knockout models. These models largely correlate well with human disease phenotypes, but can be ambiguous due to compensatory mechanisms introduced by paralogous genes. Here we present the analysis of the PTP complement of the fruit fly and the complementary view that PTP studies in Drosophila will accelerate our understanding of PTPs in physiological and pathological conditions. With only 44 PTP genes, Drosophila represents a streamlined version of the human complement. Our integrated analysis places the Drosophila PTPs into evolutionary and functional contexts, thereby providing a platform for the exploitation of the fly for PTP research and the transfer of knowledge onto other model systems.