C‐type lectin‐like domain and fibronectin‐like type II domain of phospholipase A 2  receptor 1 modulate binding and migratory responses to collagen | Zendy

Takahashi Soichiro | Zendy; Watanabe Kazuhiro | Zendy; Watanabe Yosuke | Zendy; Fujioka Daisuke | Zendy; Nakamura Takamitsu | Zendy; Nakamura Kazuto | Zendy; Obata Jun-ei | Zendy; Kugiyama Kiyotaka | Zendy

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C‐type lectin‐like domain and fibronectin‐like type II domain of phospholipase A 2 receptor 1 modulate binding and migratory responses to collagen

Author(s) -

Takahashi Soichiro,

Watanabe Kazuhiro,

Watanabe Yosuke,

Fujioka Daisuke,

Nakamura Takamitsu,

Nakamura Kazuto,

Obata Jun-ei,

Kugiyama Kiyotaka

Publication year - 2015

Publication title -

febs letters

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.593

H-Index - 257

eISSN - 1873-3468

pISSN - 0014-5793

DOI - 10.1016/j.febslet.2015.02.016

Subject(s) - c type lectin , fibronectin , lectin , receptor , glycoprotein , microbiology and biotechnology , extracellular matrix , type i collagen , chemistry , extracellular , biology , biochemistry , endocrinology

Phospholipase A 2 receptor 1 (PLA 2 R) mediates collagen‐dependent migration. The mechanisms by which PLA 2 R interacts with collagen remain unclear. We produced HEK293 cells expressing full‐length wild‐type PLA 2 R or a truncated PLA 2 R that lacks fibronectin‐like type II (FNII) domains or several regions of C‐type lectin‐like domain (CTLD). We show that the CTLD1–2 as well as the FNII domain of PLA 2 R are responsible for binding to collagen and for collagen‐dependent migration. Thus, multiple regions and domains of the extracellular portion of PLA 2 R participate in the responses to collagen. These data suggest a potentially new mechanism for PLA 2 R‐mediated biological response beyond that of a receptor for secretory PLA 2 .

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