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Human EP2 prostanoid receptors exhibit more constraints to mutations than human DP prostanoid receptors
Author(s) -
Tanimoto Jun,
Fujino Hiromichi,
Takahashi Hiroki,
Murayama Toshihiko
Publication year - 2015
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/j.febslet.2015.02.006
Subject(s) - prostanoid , receptor , prostaglandin e2 receptor , class c gpcr , immune receptor , rhodopsin like receptors , pelp 1 , biology , microbiology and biotechnology , chemistry , biochemistry , nuclear receptor , gene , metabotropic receptor , agonist , transcription factor
Human D‐type prostanoid (DP) and E‐type prostanoid 2 (EP2) receptors are regarded as the most closely related receptors among prostanoid receptors. Although these receptors are generated by tandem duplication, their physiological outputs often oppose one another. In the present study, we extracted mutations occurring in the coding regions of both receptors using the 1000 genome project database and found that EP2 receptors have 8‐fold fewer amino acid mutations. We speculate that EP2 receptors exhibit more constraints to mutations than DP receptors.