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MicroRNA‐494 inhibits the growth and angiogenesis‐regulating potential of mesenchymal stem cells
Author(s) -
Chen Shiwen,
Zhao Guangfeng,
Miao Huishuang,
Tang Ruijing,
Song Yuxian,
Hu Yali,
Wang Zhiqun,
Hou Yayi
Publication year - 2015
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/j.febslet.2015.01.038
Subject(s) - mesenchymal stem cell , microrna , angiogenesis , microbiology and biotechnology , cyclin e1 , stem cell , cyclin dependent kinase 6 , cell growth , chemistry , cancer research , biology , cyclin d1 , cell , cell cycle , genetics , gene
Mesenchymal stem cells (MSCs) play an important role in the pathology of preeclampsia (PE). Our previous microarray analysis found that microRNA‐494 (miR‐494) is highly expressed in decidua‐derived MSCs (dMSCs) from PE. We hypothesized that aberrant expression of miR‐494 in dMSCs is involved in PE development. In the present study, we found that miR‐494 arrests G1/S transition in dMSCs by targeting CDK6 and CCND1. We also found that supernatant from miR‐494‐overexpressing dMSCs reduces HTR‐8/SVneo migration and impairs HUVEC capillary formation by suppressing VEGF. Taken together, we report an unrecognized mechanism of miR‐494 affecting dMSC proliferation and function in the pathology of PE.