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MicroRNA‐145 contributes to enhancing radiosensitivity of cervical cancer cells
Author(s) -
Ye Chen,
Sun Ning-xia,
Ma Yan,
Zhao Qian,
Zhang Qing,
Xu Chen,
Wang Shao-bing,
Sun Shu-han,
Wang Fang,
Li Wen
Publication year - 2015
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/j.febslet.2015.01.037
Subject(s) - radiosensitivity , microrna , cervical cancer , transcriptome , biology , cancer research , transcription factor , dna damage , cancer cell , cancer , dna repair , dna microarray , gene expression , gene , microbiology and biotechnology , dna , genetics , medicine , radiation therapy
In our study, transcriptome microarrays are used to identify differentially expressed miRNAs and mRNAs in cervical cancer specimens. We find that microRNA‐145 (miR‐145) expression is significantly decreased in cervical cancer tissues and cell lines, and is associated with advanced cancer stages, large tumor size and moderate/poor differentiation. We show that miR‐145 targets the DNA damage repair‐associated gene Helicase‐like transcription factor (HLTF), which is involved in radio‐resistance. Moreover, miR‐145 over‐expression in cervical cancer cells enhances radiosensitivity in vitro and in vivo. These results indicate that targeting miR‐145 may be a novel radiosensitizing strategy for cervical cancer.