Premium
Glucose‐6‐phosphate tips the balance in modulating apoptosis in cerebellar granule cells
Author(s) -
Bobba A.,
Amadoro G.,
La Piana G.,
Petragallo V.A.,
Calissano P.,
Atlante A.
Publication year - 2015
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/j.febslet.2015.01.031
Subject(s) - vdac1 , apoptosis , glycolysis , oxidative phosphorylation , microbiology and biotechnology , mitochondrion , chemistry , programmed cell death , phosphorylation , glyceraldehyde 3 phosphate dehydrogenase , warburg effect , biochemistry , biology , metabolism , gene expression , escherichia coli , bacterial outer membrane , gene
A metabolic shift from oxidative phosphorylation to glycolysis ( i.e . the Warburg effect) occurs in Alzheimer's disease accompanied by an increase of both activity and level of HK‐I. The findings reported here demonstrate that in the early phase of apoptosis VDAC1 activity, but not its protein level, progressively decreases, in concomitance with the physical interaction of HK‐I with VDAC1. In the late phase of apoptosis, glucose‐6‐phosphate accumulation in the cell causes the dissociation of the two proteins, the re‐opening of the channel and the recovery of VDAC1 function, resulting in a reawakening of the mitochondrial function, thus inevitably leading to cell death.