Premium
MiR‐204, down‐regulated in retinoblastoma, regulates proliferation and invasion of human retinoblastoma cells by targeting CyclinD2 and MMP‐9
Author(s) -
Wu XianJin,
Zeng Yong,
Wu ShaoKe,
Zhong JiXin,
Wang YuZhou,
Xu JunFa
Publication year - 2015
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/j.febslet.2015.01.030
Subject(s) - retinoblastoma , cancer research , biology , matrix metalloproteinase , retinoblastoma protein , cancer , cell cycle , gene , genetics
Aberrant expression of miR‐204 had been frequently reported in cancer studies; however, the mechanism of its function in retinoblastoma remained unknown. Here, we reported that miR‐204 was frequently downregulated in retinoblastoma tissues and cell lines. Enforced expression of miR‐204 inhibited retinoblastoma cells’ proliferation and invasion. In vivo study indicated that restoration of miR‐204 inhibited tumor growth. CyclinD2 and MMP‐9 were identified as potential targets of miR‐204. In addition, a reverse correlation between miR‐204 and CyclinD2 or MMP‐9 expression was noted in retinoblastoma tissues. Taken together, our results identified a crucial tumor suppressive role of miR‐204 in the progression of retinoblastoma.