Premium
APPL1 endocytic adaptor as a fine tuner of Dvl2‐induced transcription
Author(s) -
Banach-Orlowska Magdalena,
Szymanska Ewelina,
Miaczynska Marta
Publication year - 2015
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/j.febslet.2015.01.022
Subject(s) - signal transducing adaptor protein , transcription factor , wnt signaling pathway , endocytic cycle , microbiology and biotechnology , biology , transcription (linguistics) , signal transduction , gene , genetics , receptor , endocytosis , linguistics , philosophy
APPL1 is a multifunctional endocytic adaptor which acts at different steps of various signaling pathways. Here we report that APPL1 interacts with Dvl2, a protein known to activate the canonical and non‐canonical Wnt pathways. APPL1 synergizes with Dvl2 and potentiates transcription driven by AP‐1 transcription factors, specifically by c‐Jun, in non‐canonical Wnt signaling. This function of APPL1 requires its endosomal recruitment. Overproduction of APPL1 increases Dvl2‐mediated expression of AP‐1 target gene encoding metalloproteinase 1 ( MMP1 ) in a JNK‐dependent manner. Collectively, we propose a novel role of APPL1 as a positive regulator of Dvl2‐dependent transcriptional activity of AP‐1.