Premium
MiR‐155 targets TP53INP1 to regulate liver cancer stem cell acquisition and self‐renewal
Author(s) -
Liu Fengchao,
Kong Xin,
Lv Lin,
Gao Jian
Publication year - 2015
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/j.febslet.2015.01.009
Subject(s) - microbiology and biotechnology , cancer research , stem cell , biology
In liver cancer, miR‐155 up‐regulation can regulate cancer‐cell invasion. However, whether miR‐155 expression is associated with liver cancer stem cells (CSCs) remains unknown. Here, we show that miR‐155 expression is up‐regulated in tumor spheres. Knock‐down of miR‐155 resulted in suppression of tumor sphere formation, through a decrease in the proportion of CD90 + and CD133 + CSCs and in the expression of Oct4, whereas miR‐155 overexpression had the opposite effect. TP53INP1 was determined to be involved in the CSCs‐like properties that were regulated by miR‐155. Thus, miR‐155 may play an important role in promoting the generation of stem cell‐like cells and their self‐renewal by targeting the gene TP53INP1.