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The coronary artery disease‐associated gene C6ORF105 is expressed in human macrophages under the transcriptional control of PPARγ
Author(s) -
Chinetti-Gbaguidi G.,
Copin C.,
Derudas B.,
Vanhoutte J.,
Zawadzki C.,
Jude B.,
Haulon S.,
Pattou F.,
Marx N.,
Staels B.
Publication year - 2015
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/j.febslet.2015.01.002
Subject(s) - peroxisome proliferator activated receptor , coronary artery disease , gene expression , gene , medicine , transcription factor , peripheral blood mononuclear cell , biology , receptor , endocrinology , immunology , cancer research , genetics , in vitro
Coronary artery disease (CAD) is a major cause of morbidity and mortality. Mutations in C6ORF105, associated with decreased gene expression, positively correlate with the risk of CAD in Chinese populations. Moreover, the C6ORF105‐encoded protein may play a role in coagulation. Here, we report that C6ORF105 gene expression is lower in circulating mononuclear cells from obese diabetic than lean subjects. Moreover, C6ORF105 is expressed in human macrophages and atherosclerotic lesions, where its expression positively correlates with expression of the transcription factor Peroxisome Proliferator‐Activated Receptor (PPAR)γ. Activation of PPARγ increases, in a PPARγ‐dependent manner, the expression of C6ORF105 in human macrophages and atherosclerotic lesions.