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RIP140 triggers foam‐cell formation by repressing ABCA1/G1 expression and cholesterol efflux via liver X receptor
Author(s) -
He Yanhong,
Zhang Luankun,
Li Zhuoming,
Gao Hui,
Yue Zhongbao,
Liu Zhiping,
Liu Xueping,
Feng Xiaojun,
Liu Peiqing
Publication year - 2015
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/j.febslet.2015.01.001
Subject(s) - foam cell , abca1 , liver x receptor , chemistry , efflux , inflammation , microbiology and biotechnology , cholesterol , macrophage , nuclear receptor , reverse cholesterol transport , cell , lipid metabolism , receptor , cancer research , transporter , biochemistry , medicine , biology , lipoprotein , gene , in vitro , transcription factor
Receptor‐interacting protein 140 (RIP140) is a multifunctional coregulator of lipid metabolism and inflammation. However, the potential role of RIP140 in atherosclerosis remains unknown. The present study investigated the impact of RIP140 on foam cell formation, a critical step in pathogenesis of atherosclerosis. The expression of RIP140 was increased in foam cells. RIP140 overexpression resulted in decreased cholesterol efflux in macrophages and their concomitant differentiation into foam cells. Moreover, RIP140 negatively regulated the macrophage expression of ATP‐binding cassette transporters A1 and G1 (ABCA1/G1), by suppressing the expression and activity of liver X receptor (LXR). These findings shed light onto the contribution of RIP140 to the development and progression of atherosclerosis, and suggest a novel therapeutic target for the treatment of atherosclerosis.