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Cdc42 induces EGF receptor protein accumulation and promotes EGF receptor nuclear transport and cellular transformation
Author(s) -
Wang Xiao-Yu,
Gan Ming-Xi,
Li Yong,
Zhan Wei-Hua,
Han Tian-Yu,
Han Xiao-Jian,
Cheng Jin-Quan,
Wang Jian-Bin
Publication year - 2015
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/j.febslet.2014.11.049
Subject(s) - cdc42 , microbiology and biotechnology , epidermal growth factor , chemistry , protein kinase a , kinase , mapk/erk pathway , biology , receptor , biochemistry
Cdc42 is a Ras‐related small GTP‐binding protein. A previous study has shown that Cdc42 binding to the γ subunit of the coatomer protein complex (γCOP) is essential for Cdc42‐regulated cellular transformation, but the molecular mechanism involved is not well understood. Here, we demonstrate that constitutively‐active Cdc42 binding to γCOP induced the accumulation of epithelial growth factor receptor (EGFR) in the cells, sustained EGF‐stimulated extracellular signal‐regulated kinase (ERK), JUN amino‐terminal kinase (JNK) and phosphoinositide 3‐kinase (PI3K) signaling and promoted cell division. Moreover, constitutive Cdc42 activity facilitated the nuclear translocation of EGFR, and this indicates a novel mechanism through which Cdc42 might promote cellular transformation.