Desulfovibrio desulfuricans  isolates from the gut of a single individual: Structural and biological lipid A characterization | Zendy

Zhang-Sun Wei | Zendy; Augusto Luis A. | Zendy; Zhao Liping | Zendy; Caroff Martine | Zendy

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Desulfovibrio desulfuricans isolates from the gut of a single individual: Structural and biological lipid A characterization

Author(s) -

Zhang-Sun Wei,

Augusto Luis A.,

Zhao Liping,

Caroff Martine

Publication year - 2015

Publication title -

febs letters

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.593

H-Index - 257

eISSN - 1873-3468

pISSN - 0014-5793

DOI - 10.1016/j.febslet.2014.11.042

Subject(s) - lipid a , desulfovibrio , gut flora , bacteria , lipopolysaccharide , microbiology and biotechnology , biology , lipid metabolism , biochemistry , sulfate reducing bacteria , chemistry , gram negative bacteria , escherichia coli , gene , genetics , immunology

The levels of sulfate‐reducing bacteria (SRB), including Desulfovibrionaceae , in the gut increase following a fat‐enriched diet. Endotoxins from gut microbiota contribute to the inflammation process, leading to metabolic diseases. Thus, we sought to characterize the lipid A structures of Desulfovibrionaceae lipopolysaccharides (LPS) that are associated with the microbiota inflammatory properties. LPS variants were obtained from two SRB isolates from the gut of a single individual. These LPS variants shared similar lipid A moieties with Enterobacterial LPS, but differed from one another with regard to fatty‐acid numbers and endotoxic activity. This first complete structural characterization of Desulfovibrio lipid A gives new insights into previously published data on Desulfovibrio lipid A biosynthesis. LPS microdiversity within SRBs illustrates how adaptation can influence pro‐inflammatory potential.

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