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MicroRNA‐1 promotes apoptosis of hepatocarcinoma cells by targeting apoptosis inhibitor‐5 (API‐5)
Author(s) -
Li Dong,
Liu Yu,
Li Hua,
Peng Jing-Jing,
Tan Yan,
Zou Qiang,
Song Xiao-Feng,
Du Min,
Yang Zheng-Hui,
Tan Yong,
Zhou Jin-Jun,
Xu Tao,
Fu Zeng-Qiang,
Feng Jian-Qiong,
Cheng Peng,
chen Tao,
Wei Dong,
Su Xiao-Mei,
Liu Huan-Yi,
Qi Zhong-Chun,
Tang Li-Jun,
Wang Tao,
Guo Xin,
Hu Yong-He,
Zhang Tao
Publication year - 2015
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/j.febslet.2014.11.025
Subject(s) - apoptosis , microrna , microbiology and biotechnology , inhibitor of apoptosis domain , chemistry , cancer research , biology , programmed cell death , biochemistry , caspase , gene
Although microRNA-1 ( miR-1 ) is a known liver cancer suppressor, the role of miR-1 in apoptosis of hepatoma cells has remained largely unknown. Our study shows that ectopic miR-1 overexpression induced apoptosis of liver hepatocellular carcinoma (HepG2) cells. Apoptosis inhibitor 5 ( API-5 ) was found to be a potential regulator of miR-1 induced apoptosis, using a bioinformatics approach. Furthermore, an inverse relationship between miR-1 and API-5 expression was observed in human liver cancer tissues and adjacent normal liver tissues. Negative regulation of API-5 expression by miR-1 was demonstrated to promote apoptosis of HepG2 cells. Our study provides a novel regulatory mechanism of miR-1 in the apoptosis of hepatoma cells.
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