CXCL14 is no direct modulator of CXCR4 | Zendy

Otte Maik | Zendy; Kliewer Andrea | Zendy; Schütz Dagmar | Zendy; Reimann Christiane | Zendy; Schulz Stefan | Zendy; Stumm Ralf | Zendy

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CXCL14 is no direct modulator of CXCR4

Author(s) -

Otte Maik,

Kliewer Andrea,

Schütz Dagmar,

Reimann Christiane,

Schulz Stefan,

Stumm Ralf

Publication year - 2014

Publication title -

febs letters

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.593

H-Index - 257

eISSN - 1873-3468

pISSN - 0014-5793

DOI - 10.1016/j.febslet.2014.11.009

Subject(s) - cxcl14 , cxc chemokine receptors , microbiology and biotechnology , chemokine receptor , chemokine , jurkat cells , internalization , cxcr4 , chemotaxis , phosphorylation , signal transduction , chemistry , biology , cancer research , receptor , biochemistry , immunology , immune system , t cell

C‐X‐C motif chemokine 12/C‐X‐C chemokine receptor type 4 (CXCL12/CXCR4) signaling is involved in ontogenesis, hematopoiesis, immune function and cancer. Recently, the orphan chemokine CXCL14 was reported to inhibit CXCL12‐induced chemotaxis – probably by allosteric modulation of CXCR4. We thus examined the effects of CXCL14 on CXCR4 regulation and function using CXCR4‐transfected human embryonic kidney (HEK293) cells and Jurkat T cells. CXCL14 did not affect dose–response profiles of CXCL12‐induced CXCR4 phosphorylation, G protein‐mediated calcium mobilization, dynamic mass redistribution, kinetics of extracellular signal‐regulated kinase 1 (ERK1) and ERK2 phosphorylation or CXCR4 internalization. Hence, essential CXCL12‐operated functions of CXCR4 are insensitive to CXCL14, suggesting that interactions of CXCL12 and CXCL14 pathways depend on a yet to be identified CXCL14 receptor.

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