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C/EBPα controls mast cell function
Author(s) -
Kasakura Kazumi,
Takahashi Kyoko,
Itoh Tomoko,
Hosono Akira,
Nunomura Satoshi,
Ra Chisei,
Momose Yoshika,
Itoh Kikuji,
Nishiyama Chiharu,
Kaminogawa Shuichi
Publication year - 2014
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/j.febslet.2014.10.036
Subject(s) - mast cell , immune system , microbiology and biotechnology , innate immune system , interleukin 33 , biology , cellular differentiation , stimulation , chemistry , cytokine , immunology , interleukin , biochemistry , endocrinology , gene
CCAAT/enhancer binding protein alpha (C/EBPα) is a transcription factor that influences immune cell fate and differentiation. However, the effect of C/EBPα on mast cells is not fully understood. In this study, we showed that C/EBPα suppressed granule formation in mast cells and increased macrophage inflammatory protein (MIP)‐2 production from mast cells upon bacterial stimulation. These results indicate that C/EBPα regulates the balance between the allergic response and the innate immune response of mast cells. Furthermore, we showed that stimulation of mast cells with the Lactobacillus casei JCM1134 T strain during late differentiation up‐regulated C/EBPα expression in differentiated mast cells. This suggests that intestinal commensal bacteria modulate C/EBPα expression and thereby regulate mast cell function.