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Oxytocinergic circuit from paraventricular and supraoptic nuclei to arcuate POMC neurons in hypothalamus
Author(s) -
Maejima Yuko,
Sakuma Kazuya,
Santoso Putra,
Gantulga Darambazar,
Katsurada Kenichi,
Ueta Yoichi,
Hiraoka Yuichi,
Nishimori Katsuhiko,
Tanaka Shigeyasu,
Shimomura Kenju,
Yada Toshihiko
Publication year - 2014
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/j.febslet.2014.10.010
Subject(s) - arcuate nucleus , hypothalamus , oxytocin , arc (geometry) , supraoptic nucleus , medicine , endocrinology , melanocortin , neuropeptide , chemistry , receptor , biology , geometry , mathematics
Intracerebroventricular injection of oxytocin (Oxt), a neuropeptide produced in hypothalamic paraventricular (PVN) and supraoptic nuclei (SON), melanocortin‐dependently suppresses feeding. However, the underlying neuronal pathway is unclear. This study aimed to determine whether Oxt regulates propiomelanocortin (POMC) neurons in the arcuate nucleus (ARC) of the hypothalamus. Intra‐ARC injection of Oxt decreased food intake. Oxt increased cytosolic Ca 2+ in POMC neurons isolated from ARC. ARC POMC neurons expressed Oxt receptors and were contacted by Oxt terminals. Retrograde tracer study revealed the projection of PVN and SON Oxt neurons to ARC. These results demonstrate the novel oxytocinergic signaling from PVN/SON to ARC POMC, possibly regulating feeding.