Premium
Zinc finger protein ZBTB20 promotes cell proliferation in non‐small cell lung cancer through repression of FoxO1
Author(s) -
Zhao Jun-gang,
Ren Kai-ming,
Tang Jun
Publication year - 2014
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/j.febslet.2014.10.005
Subject(s) - cyclin d1 , zinc finger , cancer research , cell growth , small interfering rna , biology , cyclin e , lung cancer , psychological repression , cyclin a , cell cycle , suppressor , cyclin e1 , cell , cancer , microbiology and biotechnology , transcription factor , genetics , cell culture , medicine , transfection , gene , gene expression
In the present study, we found that ZBTB20, a member of the POK (POZ and Krüppel) family of transcriptional repressors, was significantly up‐regulated in lung cancer tissues, compared with adjacent normal tissues. Our in vitro studies further found that ZBTB20 overexpression promoted, while its inhibition using small interfering RNA suppressed cell proliferation. Consistently, key regulators in cell‐cycle progression, such as Cyclin D1, Cyclin E, P21 and P27, were also regulated by ZBTB20. At the molecular level, we further revealed that FoxO1, a tumor suppressor in multiple human cancers, was transcriptionally repressed by ZBTB20. Therefore, our results highlight an important role for ZBTB20 in controlling NSCLC development, which might be helpful to identify potential therapeutic targets for its treatment.