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MiR‐185 is involved in human breast carcinogenesis by targeting Vegfa
Author(s) -
Wang Rui,
Tian Shi,
Wang Hong-Bin,
Chu Da-Peng,
Cao Jing-Li,
Xia Hong-Fei,
Ma Xu
Publication year - 2014
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/j.febslet.2014.09.045
Subject(s) - carcinogenesis , breast cancer , vascular endothelial growth factor a , cancer research , vegf receptors , chemistry , oncology , biology , medicine , cancer , vascular endothelial growth factor
MiR‐185 expression has been associated with many cancers. However, the roles of miR‐185 in human breast cancer remain elusive. Here, we found that miR‐185 expression was decreased in human breast cancer tissues compared with healthy tissue controls. Up‐regulation of miR‐185 inhibited breast cancer cell proliferation and invasion and vice versa. MiR‐185 was shown to bind to the 3′‐untranslated region (UTR) of vascular endothelial growth factor a ( Vegfa ), and a significant inverse correlation was found between miR‐185 and Vegfa . Vegfa overexpression partially restored the inhibition of cell proliferation and invasion that was induced by miR‐185 , and vice versa. Additionally, Vegfa expression was found to be high in human breast cancer tissues. Thus, miR‐185‐mediated Vegfa targeting may be involved in breast cancer formation.