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MicroRNA‐874 inhibits cell proliferation and induces apoptosis in human breast cancer by targeting CDK9
Author(s) -
Wang Ling,
Gao Wen,
Hu Fan,
Xu Zhiyang,
Wang Fuqiang
Publication year - 2014
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/j.febslet.2014.09.035
Subject(s) - apoptosis , microrna , cancer research , cell cycle , breast cancer , cell growth , regulator , cancer , biology , microbiology and biotechnology , downregulation and upregulation , cell , cancer cell , function (biology) , chemistry , biochemistry , gene , genetics
It has been demonstrated that miR‐874 plays important roles in many types of cancers. Nevertheless, its biological function in breast cancer remains largely unknown. In this study, we found that the expression level of miR‐874 is down‐regulated in breast cancer in comparison with the adjacent normal tissues. The overexpression of miR‐874 is able to inhibit cell proliferation and induce cell apoptosis and cell cycle arrest in MCF7 and MDA‐MB‐231 cells. Using a bioinformatics method, we further show that CDK9 is a direct target of miR‐874 and that its protein level is negatively regulated by miR‐874. Therefore, the data reported in this manuscript demonstrate that miR‐874 is an important regulator in breast cancer and imply that the miR‐874/CDK9 axis has potential as a therapeutic target for breast cancer.