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Osteoclastogenic activity of translationally‐controlled tumor protein (TCTP) with reciprocal repression of p21
Author(s) -
Choi Sik-Won,
Shin Hye Kyoung,
Yang-Yen Hsin-Fang,
Lee Myeung Su,
Lee Chang Hoon,
Park Sang-Joon,
Kim Kwang-Jin,
Lee Kyunglim,
Kim Seong Hwan
Publication year - 2014
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/j.febslet.2014.09.022
Subject(s) - osteoclast , gain of function , cellular differentiation , microbiology and biotechnology , psychological repression , phenotype , function (biology) , genetically modified mouse , biology , chemistry , transgene , gene expression , gene , in vitro , biochemistry
Translationally‐controlled tumor protein (TCTP) plays a role in a number of cellular processes, but there is limited information about its function in cell differentiation. Previous observations of a twofold induction of TCTP mRNA during osteoclast differentiation prompted us to investigate its involvement in osteoclast differentiation. The osteoclastogenicity of TCTP gradually expressed during osteoclast differentiation was confirmed in mouse and human cells using loss‐of‐function studies and TCTP heterogeneous mice and transgenic mice. Higher expression ratios of TCTP to p21 could represent TCTP‐mediated phenotypic induction of osteoclast differentiation accompanied by p21 down‐regulation, attenuating the proliferation of osteoclast precursor cells.