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Cyclin D1 acts as a barrier to pluripotent reprogramming by promoting neural progenitor fate commitment
Author(s) -
Chen Chih-Lung,
Wang Liang-Jie,
Yan Yu-Ting,
Hsu Hung-Wei,
Su Hong-Lin,
Chang Fang-Pei,
Hsieh Patrick C.H.,
Hwang Shiaw-Min,
Shen Chia-Ning
Publication year - 2014
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/j.febslet.2014.08.039
Subject(s) - reprogramming , induced pluripotent stem cell , microbiology and biotechnology , biology , progenitor cell , cell fate determination , embryonic stem cell , cell , stem cell , genetics , transcription factor , gene
A short G1 phase is a characteristic feature of the cell cycle structure of pluripotent cells, and is reestablished during Yamanaka factor‐mediated pluripotent reprogramming. How cell cycle control is adjusted to meet the requirements of pluripotent cell fate commitment during reprogramming is less well understood. Elevated levels of cyclin D1 were initially found to impair pluripotency maintenance. The current work further identified Cyclin D1 to be capable of transcriptionally upregulating Pax6 , which promoted reprogramming cells to commit to a neural progenitor fate rather than a pluripotent cell fate. These findings explain the importance of reestablishment of G1‐phase restriction in pluripotent reprogramming.