Premium
MicroRNA‐29a suppresses the growth, migration, and invasion of lung adenocarcinoma cells by targeting carcinoembryonic antigen‐related cell adhesion molecule 6
Author(s) -
Han Hye Sook,
Son Seung-Myoung,
Yun Jieun,
Jo Yeong Nang,
Lee Ok-Jun
Publication year - 2014
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/j.febslet.2014.08.023
Subject(s) - adenocarcinoma , carcinoembryonic antigen , cancer research , cell adhesion molecule , cell migration , cell adhesion , metastasis , biology , cell , immunology , medicine , cancer , biochemistry
Carcinoembryonic antigen‐related cell adhesion molecule 6 (CEACAM6) is an important regulator of cell adhesion, invasion, and metastasis. The aim of this study was to evaluate the functional roles of CEACAM6 in lung adenocarcinoma and to identify miRNAs that inhibit the growth, migration, and invasion of lung adenocarcinoma cells by targeting CEACAM6 . CEACAM6 expression is associated with poor prognosis of patients with lung adenocarcinoma, and CEACAM6 has important functional roles in controlling the growth, migration, and invasion of lung adenocarcinoma cells in vitro and in vivo. Furthermore, miR‐29a can suppress the growth, migration, and invasion of lung adenocarcinoma cells by targeting CEACAM6 . Therefore, miR‐29a/CEACAM6 axis represents a potential therapeutic target for treatment of lung adenocarcinoma.