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miR‐137 effects on gastric carcinogenesis are mediated by targeting Cox‐2‐activated PI3K/AKT signaling pathway
Author(s) -
Cheng Yan,
Li Yang,
Liu Dong,
Zhang Rong,
Zhang Jun
Publication year - 2014
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/j.febslet.2014.07.012
Subject(s) - pi3k/akt/mtor pathway , protein kinase b , cancer research , carcinogenesis , chemistry , signal transduction , biology , biochemistry , gene
The discovery of microRNAs (miRNAs) provided a new avenue for early diagnosis and treatment of GC. MiR‐137 has been reported to be under‐expressed and involved in various cell processes. However, the role of miR‐137 in GC is less known. In this study, we show that miR‐137 is under‐expressed in GC and functions as a tumor suppressor through targeting Cyclooxygenase‐2 ( Cox‐2 ), which subsequently suppresses the activation of PI3K/AKT signaling pathway both in vitro and in vivo. Moreover, restored Cox‐2 expression partially abolished the tumor suppressive effects of miR‐137 in GC cells, suggesting miR‐137 may suppress GC carcinogenesis by targeting Cox‐2 .