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Rab31 is expressed in neural progenitor cells and plays a role in their differentiation
Author(s) -
Chua Christelle En Lin,
Goh Eyleen Lay Keow,
Tang Bor Luen
Publication year - 2014
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/j.febslet.2014.06.060
Subject(s) - progenitor cell , progenitor , neural stem cell , microbiology and biotechnology , chemistry , neuroscience , endocrinology , biology , stem cell
Rab31 is expressed in both GFAP‐ and nestin‐ positive fibres in regions of neurogenic potential in the adult mouse brain. To investigate the role of Rab31 in neural progenitor cells (NPCs), we cultured NPCs and found significant levels of Rab31 expression in these cells. Rab31 levels showed a sharp initial decrease and then reappeared gradually in a subpopulation of astrocytes when NPCs were induced to differentiate. Silencing of Rab31 hindered, while overexpression enhanced, the differentiation of NPCs to astrocytes. Our results suggest a previously unrecognised role for Rab31 in influencing the differentiation and fate of NPCs.