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Effects of microRNA‐30a on migration, invasion and prognosis of hepatocellular carcinoma
Author(s) -
Liu Zhaoyang,
Tu Kangsheng,
Liu Qingguang
Publication year - 2014
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/j.febslet.2014.06.037
Subject(s) - snai1 , downregulation and upregulation , cancer research , epithelial–mesenchymal transition , microrna , metastasis , hepatocellular carcinoma , regulator , cell migration , tumor progression , cell , biology , medicine , cancer , gene , biochemistry , genetics
The role of microRNA‐30a (miR‐30a) deregulation in tumor progression and its downstream signaling pathways remain unknown. Here we confirmed significant downregulation of miR‐30a in hepatocellular carcinoma (HCC) tissues and cell lines compared with non‐tumor counterparts. MiR‐30a downregulation was significantly associated with worse disease‐free survival (DFS) of HCC patients. Gain‐ and loss‐of‐function studies revealed that downregulation of miR‐30a facilitated tumor cell migration, invasion and epithelial–mesenchymal transition (EMT). We identified SNAI1 as a direct target of miR‐30a and demonstrated miR‐30a as a novel regulator of EMT by targeting SNAI1, indicating its potential therapeutic value for reducing invasion and metastasis of HCC.