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Activation of TRPV1 mediates thymic stromal lymphopoietin release via the Ca 2+ /NFAT pathway in airway epithelial cells
Author(s) -
Jia Xinying,
Zhang Hong,
Cao Xu,
Yin Yuxin,
Zhang Bo
Publication year - 2014
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/j.febslet.2014.06.018
Subject(s) - thymic stromal lymphopoietin , trpv1 , nfat , transient receptor potential channel , respiratory epithelium , microbiology and biotechnology , cytokine , immunology , chemistry , chemokine , epithelium , receptor , medicine , biology , inflammation , pathology , transcription factor , biochemistry , gene
The airway epithelium is exposed to a range of irritants in the environment that are known to trigger inflammatory response such as asthma. Transient receptor potential vanilloid 1 (TRPV1) is a Ca 2+ ‐permeable cation channel critical for detecting noxious stimuli by sensory neurons. Recently increasing evidence suggests TRPV1 is also crucially involved in the pathophysiology of asthma on airway epithelium in human. Here we report that in airway epithelial cells TRPV1 activation potently induces allergic cytokine thymic stromal lymphopoietin (TSLP) release. TSLP induction by protease‐activated receptor (PAR)‐2 activation is also partially mediated by TRPV1 channels.