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Retracted: miR‐96 /HBP1/Wnt/β‐catenin regulatory circuitry promotes glioma growth
Author(s) -
Yan Zhiyong,
Wang Jianpeng,
Wang Chao,
Jiao Yingbing,
Qi Weiguo,
Che Shusheng
Publication year - 2014
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/j.febslet.2014.06.017
Subject(s) - wnt signaling pathway , glioma , gene silencing , catenin , cancer research , cell growth , chemistry , beta catenin , biology , microbiology and biotechnology , signal transduction , gene , biochemistry
We found that miR‐96 is overexpressed in glioma, and its level inversely correlates with the survival of patients. The reduction in miR‐96 abundance suppresses the proliferation and colony formation of glioma cells. The tumorigenicity of U‐87 MG cells is reduced by miR‐96 silencing. miR‐96 contributes to the activation of Wnt/β‐catenin pathway in glioma cells. HMG‐box transcription factor 1 (HBP‐1), a Wnt/β‐catenin pathway inhibitor, is suppressed by miR‐96 . The reactivation of Wnt/β‐catenin signaling causes an increase in the proliferation of glioma cells, and a decrease in miR‐96 expression. On the other hand, HBP1 silencing promotes miR‐96 expression. Collectively, miR‐96 contributes to the progression of glioma by enhancing the activation of the Wnt/β‐catenin pathway, and the miR‐96 /HBP1/Wnt/β‐catenin regulatory circuitry promotes the proliferation of glioma cells.