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Downregulation of PPP2R5E expression by miR‐23a suppresses apoptosis to facilitate the growth of gastric cancer cells
Author(s) -
Liu Xue,
Liu Qian,
Fan Yajie,
Wang Shaohua,
Liu Xinrui,
Zhu Lihua,
Liu Min,
Tang Hua
Publication year - 2014
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/j.febslet.2014.05.068
Subject(s) - apoptosis , downregulation and upregulation , carcinogenesis , cancer , cancer cell , cell growth , cancer research , suppressor , microrna , biology , chemistry , microbiology and biotechnology , biochemistry , genetics , gene
PPP2R5E belongs to the phosphatase 2A regulatory subunit B family and acts as a tumor suppressor in human cancer. However, the role of PPP2R5E in the tumorigenesis of gastric cancer is unclear. Here, we declare that PPP2R5E is downregulated by miR‐23a and induces cell growth inhibition and apoptosis in gastric cancer cells. Furthermore, ASO‐miR‐23a suppresses tumor growth derived from MGC803 cells in vivo. PPP2R5E is identified as a new target of miR‐23a. Moreover, overexpression of PPP2R5E reversed the negative effects of miR‐23a. We highlight the significance of miR‐23a and PPP2R5E in the proliferation and apoptosis of gastric cancer cells.