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Inhibitory role of polyunsaturated fatty acids on lysophosphatidic acid‐induced cancer cell migration and adhesion
Author(s) -
Kim Eun Kyoung,
Ha Jung Min,
Kim Young Whan,
Jin Seo Yeon,
Ha Hong Koo,
Bae Sun Sik
Publication year - 2014
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/j.febslet.2014.05.052
Subject(s) - lysophosphatidic acid , polyunsaturated fatty acid , rhoa , chemistry , biochemistry , focal adhesion , adhesion , cell adhesion , microbiology and biotechnology , fatty acid , signal transduction , biology , cell , receptor , organic chemistry
Polyunsaturated fatty acids (PUFAs) have important pharmacological effects on mammalian cells. Here, we show that carboxyl group‐containing PUFAs inhibit lysophosphatidic acid (LPA)‐induced focal adhesion formation, thereby inhibiting migration and adhesion. Carboxyl group‐containing PUFAs inhibit LPA‐induced calcium mobilization, whereas ethyl ester‐group containing PUFAs have no effect. In addition, carboxyl group‐containing PUFAs functionally inhibit LPA‐dependent RhoA activation. Given these results, we suggest that PUFAs may inhibit LPA‐induced calcium/RhoA signaling pathways leading to focal adhesion formation. Carboxyl group‐containing PUFAs may have a functional role in this regulatory mechanism.