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Membrane microdomains in immunoreceptor signaling
Author(s) -
Horejsi Vaclav,
Hrdinka Matous
Publication year - 2014
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/j.febslet.2014.05.047
Subject(s) - lipid raft , lipid microdomain , raft , microbiology and biotechnology , signal transduction , biology , t cell receptor , membrane , chemistry , t cell , immunology , biochemistry , immune system , organic chemistry , copolymer , polymer
Membrane microdomains denoted commonly as lipid rafts (or membrane rafts) have been implicated in T‐cell receptor (TCR), and more generally immunoreceptor, signaling for over 25 years. However, this area of research has been complicated by doubts about the real nature (and even existence) of these membrane entities, especially because of methodological problems connected with possible detergent artefacts. Recent progress in biophysical approaches and functional studies of raft resident proteins apparently clarified many controversial aspects in this area. At present, the prevailing view is that these membrane microdomains are indeed involved in many aspects of cell biology, including immunoreceptor signaling. Moreover, several other types of raft‐like microdomains (perhaps better termed nanodomains) have been described, which apparently also play important biological roles.