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Novel aspects of RNA regulation in Staphylococcus aureus
Author(s) -
Fechter Pierre,
Caldelari Isabelle,
Lioliou Efthimia,
Romby Pascale
Publication year - 2014
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/j.febslet.2014.05.037
Subject(s) - biology , regulation of gene expression , gene expression , rna , gene , virulence , function (biology) , computational biology , staphylococcus aureus , genetics , rna binding protein , encode , microbiology and biotechnology , bacteria
A plethora of RNAs with regulatory functions has been discovered in many non‐pathogenic and pathogenic bacteria. In Staphylococcus aureus , recent findings show that a large variety of RNAs control target gene expression by diverse mechanisms and many of them are expressed in response to specific internal or external signals. These RNAs comprise trans ‐acting RNAs, which regulate gene expression through binding with mRNAs, and cis ‐acting regulatory regions of mRNAs. Some of them possess multiple functions and encode small but functional peptides. In this review, we will present several examples of RNAs regulating pathogenesis, antibiotic resistance, and host‐pathogen interactions and will illustrate how regulatory proteins and RNAs form complex regulatory circuits to express the virulence factors in a dynamic manner.