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Homeostasis of the period of post‐translational biochemical oscillators
Author(s) -
Hatakeyama Tetsuhiro S.,
Kaneko Kunihiko
Publication year - 2014
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/j.febslet.2014.05.015
Subject(s) - circadian rhythm , nutrient , homeostasis , circadian clock , competition (biology) , enzyme , limiting , chemistry , biophysics , posttranslational modification , biology , microbiology and biotechnology , biochemistry , ecology , endocrinology , mechanical engineering , engineering
Generally, circadian clocks or biological oscillations are resistant to external conditions such as temperature and nutrient concentration. We propose that enzyme‐limited competition provides a general mechanism of homeostasis of the period of post‐translational oscillators based on protein modifications, and demonstrate it by nutrient compensation in a theoretical model of cyanobacterial circadian clock. The rate change by nutrient concentration is counterbalanced by the amount of available free enzyme, which occurs because of the competition among the various substrates for the limited enzyme. The temperature and nutrient compensation are determined by the postulate that the catalytic modification reactions are rate limiting.