Induction of miR‐29a by saturated fatty acids impairs insulin signaling and glucose uptake through translational repression of IRS‐1 in myocytes | Zendy

Yang Won-Mo | Zendy; Jeong Hyo-Jin | Zendy; Park Seung-Yoon | Zendy; Lee Wan | Zendy

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Induction of miR‐29a by saturated fatty acids impairs insulin signaling and glucose uptake through translational repression of IRS‐1 in myocytes

Author(s) -

Yang Won-Mo,

Jeong Hyo-Jin,

Park Seung-Yoon,

Lee Wan

Publication year - 2014

Publication title -

febs letters

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.593

H-Index - 257

eISSN - 1873-3468

pISSN - 0014-5793

DOI - 10.1016/j.febslet.2014.05.011

Subject(s) - insulin resistance , insulin , medicine , endocrinology , myocyte , microrna , ectopic expression , psychological repression , signal transduction , downregulation and upregulation , chemistry , glucose uptake , microbiology and biotechnology , biology , gene expression , biochemistry , gene

MicroRNAs have been shown to play an important role in insulin signaling but their biological function in insulin resistance induced by saturated fatty acids (SFA) remains largely unknown. Here, we report that SFA palmitate and high fat diet (HFD) significantly increase expression of miR‐29a in myocytes. miR‐29a targets IRS‐1 3'UTR directly and represses IRS‐1 expression at the translational level. Furthermore, the ectopic expression of miR‐29a impairs insulin signaling and glucose uptake in myocytes through a substantial decrease in IRS‐1. These findings suggest that the up‐regulation of miR‐29a by SFA is causally related to the development of insulin resistance in myocytes.

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